My research is centered on deciphering pathogenesis of immunological disorders and on developing novel immune therapeutics. Autoimmune diseases, cancer immunotherapy, and vaccines are current topics. The central theme of our research is aimed to provide useful solutions for unmet medical needs. To be more specific on our works, the inhibitory receptors, e.g. FcγRIIB and PD-1, on B cells and T cells, are my long-term research interests. We investigate the fundamental aspects of immunology, e.g. germinal center reaction, as well as the molecular mechanisms of immune dysfunction, e.g. immune exhaustion. To better address the research questions, we not only used the existing animal models but also generated our own genetically modified mice for in-depth translational and preclinical studies. In addition, the antibody drug development and antibody engineering are works in progress in the laboratory. With the experimental systems we have developed, we also wish to extend our research interests to other important diseases and unsolved problems, e.g. emerging infectious diseases, neurodegenerative diseases, antibody drug delivery and so forth.

Publications:

1] FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK. J Biomed Sci. 2015;22(1):87-98. [Abstract]

2] Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. J Mol Med (Berl). 2015 Sep 16. DOI 10.1007/s00109-015-1339-2.  [Abstract]

3] Live cell imaging reveals that the inhibitory FcγRIIB destabilizes B-cell receptor membrane-lipid interactions and blocks immune synapse formation. J. Immunol, 180:793-9. 2008.  [Abstract]

4] The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway. J. Biol. Chem. 280:35247-54. 2005.  [Abstract]

5] Isolation of lipid rafts from B lymphocytes. Methods Mol. Biol. 271:213-24. 2004.  [Abstract]

6] Location is everything: lipid rafts and immune cell signaling. Annu. Rev. Immunol. 21:457-81. 2003.  [Abstract] 

1] Mechanisms of signaling through inhibitory immune receptors, e.g. FcγRIIB-mediated apoptosis in B cells

2] Studies of molecular basis of drugs and compounds that modulate innate and adaptive immunity for treatment of

    autoimmunity and anti-tumor immunity

3] Development of cell-based therapeutics using immune cells and stem cells for immunological disorders

4] Maternal and fetal medicine

1] Nucleofector II

2] MACSmix homogenizer