Ming-Cheng Tsai

 

 

Shiang-Jong Tzeng

Tsai, Ming-Cheng

Assistant Professor

MD., Ph.D., Northwestern University 

 

Address: Room 18, 11F, College of Medicine, NTU.

TEL: (02)23123456-88314

FAX: (02)23915297

email to prof. Tzeng

專長 成果 研究方向   重點設備
 

 

Specialties

1] Immunopharmacology and Antibody Drugs

2] Molecular Cell Biology

3] Obstetrics and Gynecology

 


 

Research highlights

My research is centered on deciphering pathogenesis of immunological disorders and on developing novel immune therapeutics. Autoimmune diseases, cancer immunotherapy, and vaccines are current topics. The central theme of our research is aimed to provide useful solutions for unmet medical needs. To be more specific on our works, the inhibitory receptors, e.g. FcγRIIB and PD-1, on B cells and T cells, are my long-term research interests. We investigate the fundamental aspects of immunology, e.g. germinal center reaction, as well as the molecular mechanisms of immune dysfunction, e.g. immune exhaustion. To better address the research questions, we not only used the existing animal models but also generated our own genetically modified mice for in-depth translational and preclinical studies. In addition, the antibody drug development and antibody engineering are works in progress in the laboratory. With the experimental systems we have developed, we also wish to extend our research interests to other important diseases and unsolved problems, e.g. emerging infectious diseases, neurodegenerative diseases, antibody drug delivery and so forth.

 

 

近期代表著作:

1] FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK. J Biomed Sci. 2015;22(1):87-98. [Abstract]

2] Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. J Mol Med (Berl). 2015 Sep 16. DOI 10.1007/s00109-015-1339-2.  [Abstract]

3] Live cell imaging reveals that the inhibitory FcγRIIB destabilizes B-cell receptor membrane-lipid interactions and blocks immune synapse formation. J. Immunol, 180:793-9. 2008.  [Abstract]

4] The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway. J. Biol. Chem. 280:35247-54. 2005.  [Abstract]

5] Isolation of lipid rafts from B lymphocytes. Methods Mol. Biol. 271:213-24. 2004.  [Abstract]

6] Location is everything: lipid rafts and immune cell signaling. Annu. Rev. Immunol. 21:457-81. 2003.  [Abstract] 

 


Projects

1] Inhibitory Fc receptor and other inhibitory immune receptors

2] Mechanism and application of inhibitory receptors in autoimmunity, tumor immunity, neuroinflammation and vaccination

3] Antibody gene cloning and antibody engineering, e.g. anti-influenza antibody

4] Development of antibody-based as well as cell-based immunotherapeutics

 

 


Facilities

1] Nucleofector II

2] MACSmix homogenizer

 

 

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